Depression is also known as the silent killer because those people remain silent and try to pretend everything is going well in their lives and don’t share something with others who may feel depressed somewhere. You may know depression is the third cause of mental illness and physiological disorders. Recent statistics indicate that approximately 7.1% of the USA adults are victims of depression. Some research showed that depression is the second major contributor to disability worldwide.
What is l-methylfolate?
L-methylfolate is naturally synthesized by transforming folate or folic acid with the help of the methylenetetrahydrofolate enzyme in your body. This chemical is the primary supplier of a methyl group (CH3–) required during the methylation process. The continuous process of methylation is inevitable for you to live.
The relationship between folate deficiency and depression was postulated in the 1960s. It was revealed that depressive patients have a low folate level in their blood, and studies proved that folate is effective for depression treatment. You may notice that, while you eat healthy food, you feel happy and relaxed.
However, l-methylfolate is not only promising for depression but also carries out myriad functions of your body and shows mild side effects. Therefore, it is the exclusive chemical that the US Food and Drug Administration approves as a medical supplement.
How does l-methylfolate help with depression?
L-methylfolate helps with depression via participating in the production of happiness chemicals. You know what l-methylfolate is the unique chemical that can pass through the blood-brain barrier and penetrate the brain industry, there it plays a significant role and contributes to the balancing of brain chemistry.
The use of l-methylfolate is considered indispensable to treat or lower depression symptoms. Mostly depression patients show slight or no response towards antidepressant drugs like; selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). Thus, the psychiatrist adds l-methylfolate with antidepressant drugs as a prescription. Luckily, this proves helpful and boosts the efficiency and effectiveness of antipsychotic medications.
L-methylfolate pursues your body to produce neurotransmitters such as; serotonin, dopamine, and norepinephrine and increases their levels in your brain. These chemicals are responsible for happiness and reducing anxiety levels. Their high concentration makes you happy and also reduces anxiety clouds.
After various hits and trials, it was decided that 15mg of l-methylfolate is best to treat depression disorders. Do you know, doctors gave different doses of l-methylfolate to depressive patients, and the patients of 15mg dose showed lower symptoms of depression. However, doctors prescribe 7.5mg and 15mg doses of l-methylfolate for depression treatment.
L-methylfolate helps MTHFR patients
L-methylfolate supplements are getting popularity among the MTHFR gene muted people. The MTHFR gene muted patients receive the muted gene from their parents. Due to this mutation, people produce no or less amount of MTHFR enzyme, which converts folate into active form methylfolate. Almost 60% of USA people carry MTHFR muted gene. If they use folic acid supplements cannot get benefits, and their money will be wasted. Therefore, doctors advised them to use l-methylfolate supplements instead of folic acid.
Conclusion
L-methylfolate is a promising therapy to get rid of the depression-like dilemma. Depression is a silent killer for human beings. L-methylfolate spurs the formation of mood stabilizer chemicals like; serotonin, dopamine, and norepinephrine. Thus, doctors prescribe 7.5mg or 15mg doses of l-methylfolate with SSRIs and SNRIs drugs. L-methylfolate supplements may help you to fight depression.